Anti-Mcl-1 pS159 antibodies, human and mouse

Anti-Mcl-1 pS159 antibodies, human and mouse

Clone: REA924 | Dilution: 1:50
Clone REA924 recognizes the human and mouse protein Mcl-1 phosphorylated at serine 159 (pS159). Myeloid cell leukemia-1 (Mcl-1), also known as BCL2L3, is a member of the Bcl-2 family of regulator proteins, which play an important role in the regulation of apoptosis. The two isoforms of Mcl-1 regulate cell survival and apoptosis by inhibiting apoptosis and promotion of apoptosis and death-inducing. Mcl-1 is primarily found in the outer membrane of mitochondria and mainly expressed in programmed myeloid cell differentiation.
Additional information: Clone REA924 displays negligible binding to Fc receptors.

Alternative names

MCL1BCL2L3, Bcl2-L-3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1

Technical specifications

  • Antigen: Mcl-1 pS159
  • Clone: REA924
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: MCL1BCL2L3, Bcl2-L-3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1
  • Entrez Gene ID: 4170, 17210
  • Molecular mass of antigen [kDa]: 37, 35
  • Distribution of antigen: myeloid cells, myeloid leukemia cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Kozopas, K. M. et al. (1993) MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc. Natl. Acad. Sci. U.S.A. 90(8): 3516-3520
    2. Chao, J. R. et al. (1998) mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. Mol. Cell. Biol. 18(8): 4883-4898
    3. Bingle, C. D. et al. (2000) Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death. J. Biol. Chem. 275(29): 22136-22146
    4. Maurer, U. et al. (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21(6): 749-760
Product options: 6
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JPY 24,000
for 100
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JPY 57,000

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