Anti-KIR2D antibodies, human

Anti-KIR2D antibodies, human

Clone: NKVFS1 | Dilution: 1:11
The Anti-KIR2D antibody recognizes the killer immunoglobulin-like receptor (KIR) 2D subtype on human and non-human primate cells. It recognizes all KIRs bearing two extracellular Ig-like domains, and also both activating and inhibitory KIR isoforms (KIR2DS and KIR2DL, respectively). KIRs are expressed on CD56
dim
CD16
+
natural killer (NK) cells and a subset of CD8
+
T cells. KIRs contribute to the regulation of NK cell-mediated cytotoxicity. They are monomeric receptors possessing high allelic polymorphism with either two or three Ig-like extracellular domains (KIR2D or KIR3D, respectively). According to the length of their cytoplasmic tail, KIRs can be subdivided in long-tailed inhibitory KIRs (KIR2DL or KIR3DL) and short-tailed activating KIRs (KIR2DS or KIR3DS).

Alternative names

CD158A

Technical specifications

  • Antigen: KIR2D
  • Clone: NKVFS1
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CD158A
  • Entrez Gene ID: 3806, 100132285, 3808, 3809, 3810, 3802, 3803, 3804, 3805, 57292
  • Molecular mass of antigen [kDa]: 31-39
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, VioBlue, VioGreen, Biotin, pure
  • Selected references

    1. Djeu, J. et al. (2002) A view to a kill: signals triggering cytotoxicity. Clin. Cancer Res. 8: 636-640
    2. Hsu, K. et al. (2002) The killer cell immunoglobin-like (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol. Rev. 190: 40-52
    3. Selvakumar, A. et al. (1997) Polymorphism and domain variability of human killer cell inhibitory receptors. Immunol. Rev. 155: 183-196
  • Customer reports and application notes

Product options: 11
for 30
tests
(1)
JPY 22,000
for 100
tests
(1)
JPY 52,000
for 30
tests
(1)
JPY 26,000
for 100
tests
(1)
JPY 62,000
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 58,000
for 30
tests
JPY 24,000
for 100
tests
JPY 58,000
for 30
tests
(1)
JPY 22,000
for 100
tests
(1)
JPY 52,000
100 µg in 1 mL
JPY 37,000

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