Anti-Jak1 antibodies, human, mouse, rat

Anti-Jak1 antibodies, human, mouse, rat

Clone: REA700 | Dilution: 1:50
Clone REA700 recognizes the human, mouse, and rat Jak1 antigen, also known as tyrosine-protein kinase JAK1 or janus kinase 1. Jak1 is a widely expressed membrane-associated phosphoprotein characterized by the presence of a second phosphotransferase-related domain immediately N terminal to the PTK domain. Jak1 is involved in the IFN-α/β/γ signal pathway and activates transcription factors of the STAT family by phosphorylating critical tyrosine regulatory sites.
Additional information: Clone REA700 displays negligible binding to Fc receptors

Alternative names

Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1

Technical specifications

  • Antigen: Jak1
  • Clone: REA700
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1
  • Entrez Gene ID: 3716, 16451, 84598
  • Molecular mass of antigen [kDa]: 133
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Wilks, A. F. et al. (1991) Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell. Biol. 11(4): 2057-2065
    2. Williams, N. K. et al. (2009) Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase Domains. J. Mol. Biol. 387(1): 219-232
Product options: 4
for 30
tests
(1)
JPY 26,000
for 100
tests
(1)
JPY 62,000
for 30
tests
(1)
JPY 26,000
for 100
tests
(1)
JPY 62,000

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