Anti-IRF-4 antibodies, human and mouse

Anti-IRF-4 antibodies, human and mouse

Clone: REA201 | Dilution: 1:11
Clone REA201 recognizes IRF-4, which is a 52 KDa transcription factor and belongs to the family of interferon regulatory transcription factors (IRF).The IRF family consists of nine members in both human and mice and is characterized by a conserved N-terminal DNA-binding domain (DBD) with unique tryptophan pentad repeat and modulates the expression of genes regulated by the presence of interferons and in response to cell activation. Expression of IRF-4 is found in cells of the immune system, including lymphocytes, dendritic cells, and macrophages, where it's multiple functions include regulation of cell proliferation, apoptosis, and differentiation. Transcriptional activity of IRF-4 is further modulated by its interaction with various co-factors including including Pu.1, E47, STAT-6, and IRF-8.
Additional information: Clone REA201 displays negligible binding to Fc receptors.

Alternative names

IRF4, LSIRF, MUM1, NF-EM5, SHEP8, Spip, ICSAT14, LSIRF13

Technical specifications

  • Antigen: IRF-4
  • Clone: REA201
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IRF4, LSIRF, MUM1, NF-EM5, SHEP8, Spip, ICSAT14, LSIRF13
  • Entrez Gene ID: 3662
  • Molecular mass of antigen [kDa]: 52
  • Distribution of antigen: B cells, T cells, macrophages, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
  • Selected references

    1. Klein, U. et al. (2006) Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat. Immunol. 7(7): 773-782
    2. Nayar, R. et al. (2012)
      TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8
      +
      T-cell differentiation.
      Proc. Natl. Acad. Sci. U.S.A. 109: E2794-E2802
    3. Biswas, P. S. et al. (2012) Dual regulation of IRF4 function in T and B cells is required for the coordination of T–B cell interactions and the prevention of autoimmunity. J. Exp. Med. 209: 581-596
Product options: 6
for 30
tests
(1)
JPY 26,000
for 100
tests
(1)
JPY 62,000
for 30
tests
(1)
JPY 26,000
for 100
tests
(1)
JPY 62,000
for 30
tests
(1)
JPY 25,000
for 100
tests
(1)
JPY 59,000

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