Anti-IL-17F antibodies, mouse

Anti-IL-17F antibodies, mouse

Clone: REA666 | Dilution: 1:50
Clone REA666 recognizes the mouse interleukin 17F (IL-17F) antigen, a cytokine which is expressed by a subset of activated T cells in the lamina propria. IL-17F belongs to the IL-17 gene family, which consists of six members (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F). All members have a similar protein structure, with four highly conserved cysteine residues critical to their 3-dimensional shape. The isoforms of IL-17F 1 and 2 (ML-1) have the highest homology to IL-17A. It has been reported, that IL-17–producing T lymphocytes comprise a distinct lineage of proinflammatory T helper cells, termed Tʜ17 cells, that are major contributors to autoimmune disease. IL-17F plays a role in the induction of neutrophilia in the lungs and in the exacerbation of Ag-induced pulmonary inflammation.
Additional information: Clone REA666 displays negligible binding to Fc receptors.

Alternative names

Interleukin-17F

Technical specifications

  • Antigen: IL-17F
  • Clone: REA666
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Interleukin-17F
  • Entrez Gene ID: 257630
  • Molecular mass of antigen [kDa]: 15
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Ivanov, I. I. et al. (2006)
      The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17
      +
      T helper cells.
      Cell 126: 1121-1133
    2. Suzuki, S. et al. (2007) Expression of interleukin-17F in a mouse model of allergic asthma. Int. Arch. Allergy Immunol. 143: 89-94
    3. Oda, N. et al. (2005) Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic response. Am J Respir Crit Care Med. 171(1): 12-18
Product options: 4
30 µg in 200 µL (1)
JPY 7,500
150 µg in 1 mL (1)
JPY 22,000
30 µg in 200 µL (1)
JPY 12,000
30 µg in 200 µL (1)
JPY 12,000

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