Anti-Ikaros antibodies, mouse

Anti-Ikaros antibodies, mouse

Clone: REA919 | Dilution: 1:50
Clone REA919 recognizes the mouse Ikaros protein, also known as DNA-binding protein Ikaros, Ikaros family zinc finger protein 1, or IKZF1. Ikaros is a transcription regulator of hematopoietic cell differentiation of lymphocytes, B cells, and T cells, and functions as a major tumor suppressor involved in human B cell acute lymphoblastic leukemia. In association with other Ikaros-family members, e.g. Aiolos and Helios, Ikaros forms heterodimers, that are important for normal progression to a mature and immunocompetent state. Ikaros is found in the nucleus to a higher extent in granulocytes, B cells, T cells, and NK cells, and in lower levels in erythroblasts, megakaryocytes, and monocytes.
Additional information: Clone REA919 displays negligible binding to Fc receptors.

Alternative names

Ikaros family zinc finger protein 1, Lyf1, Zfpn1a1, Znfn1a1, Ikzf1

Technical specifications

  • Antigen: Ikaros
  • Clone: REA919
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Ikaros family zinc finger protein 1, Lyf1, Zfpn1a1, Znfn1a1, Ikzf1
  • Entrez Gene ID: 22778
  • Molecular mass of antigen [kDa]: 57
  • Distribution of antigen: B cells, granulocytes, monocytes, megakaryocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Morgan, B. et al. (1997) Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16(8): 2004-2013
    2. Watkins, N. A. et al. (2009) A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood 113(19)
    3. Kastner, P. et al. (2011) Role of Ikaros in T-cell acute lymphoblastic leukemia. J. Biol. Chem. 2(6): 108-114
Product options: 6
30 µg in 200 µL (1)
JPY 7,500
150 µg in 1 mL (1)
JPY 22,000
30 µg in 200 µL (1)
JPY 12,000
150 µg in 1 mL (1)
JPY 35,000
30 µg in 200 µL (1)
JPY 12,000
150 µg in 1 mL (1)
JPY 35,000

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