Anti-IFN-α antibodies, human

Anti-IFN-α antibodies, human

Clone: LT27:295 | Dilution: 1:10
Type I interferons (IFNs), including IFN-α, are a family of cytokines that exert pleiotropic functions in the immune system. Besides its potent antiviral activity, IFN-α exerts a variety of immunomodulatory effects, including positive and negative regulation of its own production, regulation of IL-12 and IFN-γ production, promotion of natural killer (NK) cell cytotoxicity, activation and maturation of dendritic cells, and the promotion of B cell development towards plasma cells. IFN-α is expressed predominantly by CD123
+
CD11c
-
CD303 (BDCA2)
+
plasmacytoid dendritic cells (pDCs). Clone LT27:295 recognizes the majority of the IFN-α subtypes, but not IFN-α2b.

Alternative names

IFNA1

Technical specifications

  • Antigen: IFN-α
  • Clone: LT27:295
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: IFNA1
  • Entrez Gene ID: 3439, 3440, 3451, 3445, 3447, 3452, 3441, 3446, 3448, 3442
  • Molecular mass of antigen [kDa]: 19-20
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, pure
  • Selected references

    1. Ronnblom, L. and Alm, G. V. (2001) An etiopathogenic role for the type I IFN system in SLE. Trends Immunol. 22: 427-431
    2. Båve, U. et al. (2003) FcγRIIa is expressed on natural IFN-α-producing cells (plasmacytoid dendritic cells) and is required for the IFN-α production induced by apoptotic cells combined with lupus IgG. J. Immunol. 171: 3296-3302
Product options: 7
for 30
tests
(1)
JPY 22,000
for 100
tests
(1)
JPY 52,000
for 30
tests
(1)
JPY 26,000
for 100
tests
(1)
JPY 62,000
for 30
tests
(1)
JPY 26,000
for 100
tests
(1)
JPY 62,000
100 µg in 1 mL
JPY 30,000

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