Anti-HLA-E antibodies, human

Anti-HLA-E antibodies, human

Clone: REA1031 | Dilution: 1:50
Clone REA1031 recognizes the human HLA-E protein, a member of the human leukocyte antigen family. HLA-E is a non-classical MHC molecule (MHC-Ib) with limited polymorphisms, which is expressed on the cell surface in a heterodimeric complex with β2-microglobulin. HLA-E is ubiquitously expressed and has a specialized role in NK cell recognition. It binds a restricted set of peptides, e.g., derived from other class I leader sequences. The complex is recognized by NKG2A on natural killer (NK) cells. This recognition protects the HLA-E–expressing cell from NK cell killing. Recently HLA-E recognition by a specialised subset of CD8 T cells has been implicated in pathogen recognition as well as autoimmunity.
Additional information: Clone REA1031 displays negligible binding to Fc receptors.

Alternative names

QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E

Technical specifications

  • Antigen: HLA-E
  • Clone: REA1031
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E
  • Entrez Gene ID: 3133
  • Molecular mass of antigen [kDa]: 38
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, Biotin
  • Selected references

    1. Lu, L. et al. (2008)
      Generation and regulation of CD8
      +
      regulatory T cells.
      Cell. Mol. Immunol. 5(6): 401-406
    2. Jiang, H. et al. (2010)
      HLA-E-restricted regulatory CD8
      +
      T cells are involved in development and control of human autoimmune type 1 diabetes.
      J. Clin. Invest. 120(10): 3641-3650
    3. Pietra, G. et al. (2010)
      The emerging role of HLA-E-restricted CD8
      +
      T lymphocytes in the adaptive immune response to pathogens and tumors.
      J. Biomed. Biotechnol. : 907092
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