Anti-FcεRIα antibodies, human

Anti-FcεRIα antibodies, human

Clone: REA758 | Dilution: 1:50
Clone REA758 recognizes the human FcεRIα, the α subunit of the human high-affinity Fc receptor for IgE. The receptor is composed of one α-, one β-, and two disulphide-linked γ-chains, of which the α subunit binds IgE1. FcεRIα is expressed on mast and basophil cells, is upregulated in the presence of IgE, and is found on a subset of blood dendritic cells. The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions.
Additional information: Clone REA758 displays negligible binding to Fc receptors.

Alternative names

FCER1A, Fce1a, FcERI

Technical specifications

  • Antigen: FcεRIα
  • Clone: REA758
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FCER1A, Fce1a, FcERI
  • Entrez Gene ID: 2205
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: mast cells, basophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700
  • Selected references

    1. Hakimi, J. et al. (1990) The alpha subunit of the human IgE receptor (FcERI) is sufficient for high affinity IgE binding. J. Biol. Chem. 265: 22079-22081
    2. Hasegawa, S. et al. (1999) Functional expression of the high affinity receptor for IgE (FcepsilonRI) in human platelets and its`intracellular expression in human megakaryocytes. Blood 93: 2543-2551
    3. Takai, T. et al. (2000) Epitope analysis and primary structures of variable regions of anti-human FcepsilonRI monoclonal antibodies, and expression of the chimeric antibodies fused with human constant regions. Biosci. Biotechnol. Biochem. 64: 1856-1867
    4. Suzukawa, M. et al. (2005) IgE- and FcepsilonRI-mediated migration of human basophils. Int. Immunol. 17: 1249-1255
    5. Yokoi, H. et al. (2008) Inhibition of Fcepsilon RI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. J. Allergy Clin. Immunol. 121: 499-505
    6. Hammad, H. et al. (2010) Inflammatory dendritic cells–not basophils–are necessary and sufficient for induction of Tʜ2 immunity to inhaled house dust mite allergen. J. Exp. Med. 207: 2097-2111
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