Anti-DR3 antibodies, mouse

Anti-DR3 antibodies, mouse

Clone: REA475 | Dilution: 1:10
Clone REA475 recognizes the mouse DR3 antigen, a member of the TNF-receptor superfamily which is also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25). DR3 is the receptor for TNFSF12 (APO3L, TWEAK) and interacts directly with the adapter TRADD. It is expressed primarily by CD4
+
and CD8
+
T and NKT cells. DR3 is also highly expressed by FoxP3 positive regulatory T lymphocytes. It mediates activation of NFκB and induces apoptosis. DR3 is activated by TNFSF15, which is rapidly upregulated in antigen presenting cells and some endothelial cells following toll-like receptor or Fc receptor activation.
Additional information: Clone REA475 displays negligible binding to Fc receptors.

Alternative names

TNFRSF25, Apo-3, DDR3, LARD, TR3, TRAMP, Tnfrsf12, WSL-1, DR3, WSL-1-like

Technical specifications

  • Antigen: DR3
  • Clone: REA475
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: TNFRSF25, Apo-3, DDR3, LARD, TR3, TRAMP, Tnfrsf12, WSL-1, DR3, WSL-1-like
  • Entrez Gene ID: 85030
  • Molecular mass of antigen [kDa]: 44
  • Distribution of antigen: T cells, T helper cells, NKT cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, Biotin
  • Selected references

    1. Kitson, J. et al. (1996) A death-domain-containing receptor that mediates apoptosis. Nature 384(6607): 372-375
    2. Schreiber, T. H. et al. (2010) Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J. Clin. Invest. 120(10): 3629-3640
    3. Schreiber, T. H. et al. (2013) Immunobiology of TNFSF15 and TNFRSF25. Immunol. Res. 57(1-3): 3-11
Product options: 4
9 µg in 300 µL (1)
JPY 4,800
30 µg in 1 mL (1)
JPY 12,000
9 µg in 300 µL (1)
JPY 2,800
30 µg in 1 mL (1)
JPY 7,500

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