Anti-DR3 antibodies, human

Anti-DR3 antibodies, human

Clone: JD3 | Dilution: 1:11
Clone JD3 recognizes the human DR3 antigen, a member of the TNF-receptor superfamily which is also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25). DR3 is the receptor for TNFSF12 (APO3L, TWEAK) and interacts directly with the adapter TRADD. It mediates activation of NFκB and induces apoptosis. DR3 is expressed preferentially by activated and antigen-experienced T lymphocytes. It is also highly expressed by FoxP3-positive regulatory T lymphocytes. DR3 is activated by TNFSF15, which is rapidly upregulated in antigen-presenting cells and some endothelial cells following toll-like receptor or Fc receptor activation. Multiple alternatively spliced transcript variants of this gene-encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of DR3 in B and T cells encounters a programmed change upon T cell–activation, which predominantly produces full-length, membrane-bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T cell–activation. DR3 stimulation is therefore highly specific to T cell–mediated immunity, which can be used to enhance or dampen inflammation depending on the temporal context and quality of foreign versus self antigen availability. Stimulation of DR3 in humans leads to similar effects as costimulatory blockade targeting molecules such as CTLA-4 and PD-1.

Alternative names

TNFRSF25, Apo-3, DDR3, LARD, Tnfrsf12, TR3, TRAMP, WSL-1, WSL-LR

Technical specifications

  • Antigen: DR3
  • Clone: JD3
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: TNFRSF25, Apo-3, DDR3, LARD, Tnfrsf12, TR3, TRAMP, WSL-1, WSL-LR
  • Entrez Gene ID: 8718
  • Molecular mass of antigen [kDa]: 43
  • Distribution of antigen: T cells, lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Meylan, F. et al. (2008) The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 29(1): 79-89
    2. Kitson, J. et al. (1996) A death-domain-containing receptor that mediates apoptosis. Nature 384(6607): 372-375
    3. Chinnaiyan, A. M. et al. (1996) Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 274(5289): 990-992
Product options: 6
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000

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