Anti-CCL3 (MIP-1α) antibodies, mouse

Anti-CCL3 (MIP-1α) antibodies, mouse

Clone: REA355 | Dilution: 1:10
Clone REA355 recognizes the mouse C-C motif chemokine 3 (CCL3) antigen also known as Macrophage inflammatory protein 1 α (MIP-1a). CCL3 is a cytokine belonging to the members of the β (CC) subfamily of chemokines. It is produced by T cells, B cells, Langerhans cells, neutrophils and macrophages. CCL3 is involved in activation and recruitment of lymphocytes, monocytes, and granulocytes during acute inflammation and plays a role as a chemoattractant of monocytes, B cells, eosinophils and cytotoxic T cells. It has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for CCL3 has been identified as CCR1 and CCR5. CCL3 deficient mice showed increased resistance to viral-induced mortality following infection with HSV-1.
Additional information: Clone REA355 displays negligible binding to Fc receptors.

Alternative names

LD78alpha, MIP1-alpha, MIP1A, Scya3, L2G25B, SIS-α, Small-inducible cytokine A3, TY-5

Technical specifications

  • Antigen: CCL3 (MIP-1α)
  • Clone: REA355
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: LD78alpha, MIP1-alpha, MIP1A, Scya3, L2G25B, SIS-α, Small-inducible cytokine A3, TY-5
  • Entrez Gene ID: 20302
  • Molecular mass of antigen [kDa]: 8
  • Distribution of antigen: T cells, B cells, Langerhans cells, neutrophils, macrophages
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Bernardini, G. et al. (2008) CCL3 and CXCL12 regulate trafficking of mouse bone marrow NK cell subsets. Blood 111(7): 3626-3634
    2. Fujita, H. et al. (2004) Expression and regulation of RANTES/CCL5, MIP-1alpha/CCL3, and MIP-1beta/CCL4 in mouse Langerhans cells. J. Invest. Dermatol. 122(5): 1331-1333
    3. Grove, M. et al. (1990) Sequence of the murine haemopoietic stem cell inhibitor/macrophage inflammatory protein 1 alpha gene. Nucleic Acids Res. 18(18): 5561
Product options: 4
9 µg in 300 µL (1)
JPY 4,800
30 µg in 1 mL (1)
JPY 12,000
9 µg in 300 µL (1)
JPY 7,000
30 µg in 1 mL (1)
JPY 12,000

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