Anti-Aiolos antibodies, human

Anti-Aiolos antibodies, human

Clone: REA881 | Dilution: 1:50
Clone REA881 recognizes the human transcription factor aiolos, also known as IKZF3. Aiolos is a member of the ikaros family of zinc-finger proteins and forms heterodimers with other ikaros family members. It plays an essential role in the control of B lymphocyte differentiation and proliferation and in the regulation of BCL2 expression. Furthermore, it is involved in controlling apoptosis in T cells in an IL-2–dependent manner. Aiolos is found in peripheral blood leukocytes, spleen, and thymus.
Additional information: Clone REA881 displays negligible binding to Fc receptors.

Alternative names

IKZF3, Znfn1a3

Technical specifications

  • Antigen: Aiolos
  • Clone: REA881
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IKZF3, Znfn1a3
  • Entrez Gene ID: 22806
  • Molecular mass of antigen [kDa]: 58
  • Distribution of antigen: spleen
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, Vio515
  • Selected references

    1. Romero, F. et al. (1999) Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. EMBO J. 18(12): 3419-3430
    2. Caballero, R. et al. (2007) Combinatorial effects of splice variants modulate function of Aiolos. J. Cell. Sci. 120(15): 2619-2630
    3. Billot, K. et al. (2010) Differential aiolos expression in human hematopoietic subpopulations. Leuk. Res. 34(3): 289-293
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