Anti-PSA-NCAM MicroBeads, human, mouse, rat

Anti-PSA-NCAM MicroBeads, human, mouse, rat

Anti-PSA-NCAM MicroBeads have been developed for the positive selection or depletion of PSA-NCAM
cells from tissue or cell culture.

Background information

Anti-PSA-NCAM MicroBeads recognize polysialic acid (PSA), which is linked to the extracellular domain of the neural cell adhesion molecule (NCAM, CD56).
PSA-NCAM, the highly polysialated form of NCAM, is predominantly expressed in embryonic and neonatal neural tissue
. In adult mammalian brain PSA-NCAM expression is restricted mainly to areas that retain neurogenic potential, such as the subventricular zone (SVZ)
and the dentate gyrus of the hippocampus.
PSA-NCAM is a marker for immature neuronal-committed progenitors that are permanently generated in the SVZ and migrate along a well-defined pathway, the rostral migratory stream, into the olfactory bulb where they differentiate into GABAergic and dopaminergic interneurons.
PSA-NCAM positive neuronal precursors have been isolated from rat forebrain and from mouse SVZ tissue after depletion of A2B5
glial progenitor cells.


For positive selection: MS, LS, or autoMACS
Columns. For depletion: LD or autoMACS Columns.
Product options: 1
for 5×
total cells
JPY 91,000

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