CD1a MicroBeads, human

CD1a MicroBeads, human

CD1a MicroBeads have been developed for positive selection of CD1a
+
dendritic cells from epidermis (Langerhans cells), dermis, lung, mucosa, and other non-lymphoid tissues or for further purification of CD1a
+
dendritic cells generated
ex vivo
from CD34
+
or CD133
+
hematopoietic progenitor cells.

Background information

The CD1a antigen is a member of the CD1 family of proteins, which are structurally related to MHC class I proteins and mediate the presentation of non-peptide antigens to T cells.
1

Applications

CD1a MicroBeads were used, for example, for the isolation of Langerhans cells from epidermis
2
or for isolation of hematopoietic progenitor cell-derived dendritic cells.
3

Columns

For positive selection: MS, LS, XS, or autoMACS® Columns. Large Cell Columns are recommended for the isolation of Langerhans cells from skin.
  • Selected references

    1. Brigl, M. and Brenner, M. B. (2004) CD1: antigen presentation and T cell function. Annu. Rev. Immunol. 22: 817-890
    2. Simon, J. C. et al. (1995) Rapid purification of human Langerhans cells using paramagnetic microbeads. Exp. Dermatol. 4: 155-161
    3. Ye, Z. et al. (1996)
      In vitro
      expansion and characterization of dendritic cells derived from human bone marrow CD34
      +
      cells.
      Bone Marrow Transplant. 18: 997-1008
Product options: 1
for 1×
10
9
total cells
JPY 104,000

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