Mouse IL-27-A

Mouse IL-27-A

IL-27-A stands for interleukin 27 subunit alpha. Mouse IL-27 subunit alpha is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IL-27-A can be used for a variety of applications including:
  • Tʜ1 cell differentiation.
  • Research on autoimmune diseases.
  • Cancer Research.

Background information

Interleukin 27 subunit alpha (IL-27-A) together with EBI3 (IL-27 subunit beta) forms the heterodimeric protein IL-27. Produced as an early product of antigen-presenting cells (APC), IL-27 plays a role in the adaptive immune response by promoting the clonal expansion of naive CD4
+
T cells. IL-27 can stimulate Tʜ1 differentiation and seems to be a potent inhibitor of Tʜ17 cell development and of IL-17 production. It has also been shown that IL-27 has the ability to induce CD8
+
-mediated tumor-specific protective immunity.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Inhibition of TGF-beta and IL-6-induced IL-17A expression in mouse CD4 splenocytes
  • research grade: ≥ 2×
    10
    4
    U/mg
  • Certificates

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    link
    to search for Certificates of Analysis (CoA) by lot number.
Product options: 2
E. coli
2 µg
JPY 11,000
E. coli
10 µg
JPY 37,000