Clone:
REA1169
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
TNF-beta, TNF-b, LT-alpha, LT-α

Specifications for TNF-β Antibody, anti-human, REAfinity™

Overview

Clone REA1169 recognizes the human TNF-β antigen, a cytokine belonging to the tumor necrosis factors (TNF) family. TNF-β is also known as lymphotoxin-a and is produced by activated lymphocytes, for example CD4
+
and CD8
+
T cells and some B lymphoblastoid cell lines. TNF-β and TNF-α, which have similar biological activities and same receptors, are able to inhibit tumor growth. TNF-β induces the synthesis of GM-CSF, G-CSF, interleukin 1 (IL-1), collagenase, and is a mitogen for B-lymphocytes.
Additional information: Clone REA1169 displays negligible binding to Fc receptors.

Alternative names

TNF-beta, TNF-b, LT-alpha, LT-α

Detailed product information

Technical specifications

CloneREA1169
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTNF-β
Alternative names of antigenTNF-beta, TNF-b, LT-alpha, LT-α
Molecular mass of antigen [kDa]19
Distribution of antigenT cells, B cells
Entrez Gene ID4049
RRIDAB_2801793, AB_2801796, AB_2801794, AB_2801795

References for TNF-β Antibody, anti-human, REAfinity™

Publications

  1. Nedospasov, S. A. et al. (1985) Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome. Cold Spring Harb. Symp. Quant. Biol. 51(1): 611-624
  2. Nedwin, G. E. et al. (1985) Structure and chromosomal localization of the human lymphotoxin gene. J. Cell. Biochem. 29(3): 171-181
  3. Browning, J. L. et al. (1993) Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell 72(6): 847-856

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