Clone:
REA514
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TREML2, C6orf76, TLT2

Specifications for TLT-2 Antibody, anti-human, REAfinity™

Overview

Clone REA514 recognizes the human Trem-like transcript 2 (TLT-2) antigen, a single-pass type I membrane protein, which is also known as triggering receptor expressed on myeloid cells-like protein 2 (TREML2). TLT-2 is one of the conserved TREM family members, which is expressed on B cells, T cells, macrophages, and neutrophils. It is suggested to play an important role in the immune system, for it is not only highly expressed in inflammation, but also promotes the proliferation of T cells and the production of cytokines.
Additional information: Clone REA514 displays negligible binding to Fc receptors

Alternative names

TREML2, C6orf76, TLT2

Detailed product information

Technical specifications

CloneREA514
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTLT-2
Alternative names of antigenTREML2, C6orf76, TLT2
Molecular mass of antigen [kDa]33
Distribution of antigenT cells, B cells, macrophages
Entrez Gene ID79865
RRIDAB_2654195, AB_2654196, AB_2654197, AB_2654194

Resources for TLT-2 Antibody, anti-human, REAfinity™

References for TLT-2 Antibody, anti-human, REAfinity™

Publications

  1. Halpert, M. M. et al. (2011) TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling. J. Immunol. 187(5): 2346-2355
  2. Hashiguchi, M. et al. (2008) Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses. Proc. Natl. Acad. Sci. U.S.A. 105(30): 10495-10500
  3. Allcock, R. J. et al. (2003) The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur. J. Immunol. 33(2): 567-577

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