Clone:
REA654
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
TCR Vb2, TCR Vbeta2, TCRBV22S1A2N1T, TCRBV2S1

Specifications for TCR Vβ2 Antibody, anti-human, REAfinity™

Overview

Clone REA654 recognizes the human variable β2 subunit of the α/β T cell receptor (TCR Vβ2). The TCR is a heterodimeric glycoprotein associated with the CD3 antigen. The α and β TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vβ2 is a variant of the TCR β chain. α/β T cells express a diverse α/β TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell–mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of α/β T cell–mediated immunity and underpins MHC restriction.
Additional information: Clone REA654 displays negligible binding to Fc receptors.

Alternative names

TCR Vb2, TCR Vbeta2, TCRBV22S1A2N1T, TCRBV2S1

Detailed product information

Technical specifications

CloneREA654
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTCR Vβ2
Alternative names of antigenTCR Vb2, TCR Vbeta2, TCRBV22S1A2N1T, TCRBV2S1
Molecular mass of antigen [kDa]11
Distribution of antigenT cells
Entrez Gene ID28620
RRIDAB_2857799, AB_2921744, AB_2921742, AB_2905434, AB_2905433, AB_2857609, AB_2857596, AB_2653840, AB_2653841, AB_2653842, AB_2653843, AB_2653844, AB_2653845, AB_2653846, AB_2653847, AB_2922275, AB_2922269, AB_2928908, AB_2928907, AB_2928906, AB_2928905, AB_2857809

Resources for TCR Vβ2 Antibody, anti-human, REAfinity™

Certificates

Please follow this
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References for TCR Vβ2 Antibody, anti-human, REAfinity™

Publications

  1. Born, W. et al. (1985) Rearrangement of T-cell receptor beta-chain genes during T-cell development. Proc. Natl. Acad. Sci. U.S.A. 82(9): 2925-2929
  2. van den Beemd, R. et al. (2000) Flow cytometric analysis of the Vbeta repertoire in healthy controls. Cytometry 40(4): 336-345
  3. Trautmann, A. et al. (2003) Human CD8 T cells of the peripheral blood contain a low CD8 expressing cytotoxic/effector subpopulation. Immunology 108(3): 305-312

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