Clone:
REA393
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
CD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14

Specifications for Siglec-5/Siglec-14 Antibody, anti-human, REAfinity™

Overview

Clone REA393 recognizes the human siglec-5 and siglec-14 antigens, which are both single pass transmembrane protein members of the immunoglobulin superfamily. Siglec-5 is also known as CD170. Siglec-5 has four extracellular Ig-like domains and a cytosolic inhibitory motif. Siglec-14 was discovered with three Ig-like domains and has almost complete sequence identity with siglec-5 at the first two Ig-like domains, shows a glycan binding preference similar to that of siglec-5, and associates with the activating adapter protein DAP12. Siglec-5 is expressed on granulocytes and monocytes as well as on plasmacytoid dendritic cells, monocyte-derived dendritic cells, and macrophages. It is potentially involved in the negative regulation of innate immune responses, and also suggested to be a useful diagnostic and therapeutic marker for acute myelogenous leukemia. Siglec-14 is expressed on granulocytes and B cells. Some individuals lack the expression of siglec-14, while they all express siglec-5.
Additional information: Clone REA393 displays negligible binding to Fc receptors.

Alternative names

CD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14

Detailed product information

Technical specifications

CloneREA393
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenSiglec-5/Siglec-14
Alternative names of antigenCD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14
Molecular mass of antigen [kDa]51
Distribution of antigenmonocytes, granulocytes, dendritic cells, B cells, macrophages
Entrez Gene ID8778, 100049587
RRIDAB_2819695, AB_2653414, AB_2653415, AB_2653416, AB_2653417, AB_2653418, AB_2653419, AB_2653420, AB_2653421, AB_2653422, AB_2653423, AB_2819703

Resources for Siglec-5/Siglec-14 Antibody, anti-human, REAfinity™

References for Siglec-5/Siglec-14 Antibody, anti-human, REAfinity™

Publications

  1. Cornish, A. L. et al. (1998) Characterization of Siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. Blood 92(6): 2123-2132
  2. Ali, S. R. et al. (2014) Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J. Exp. Med. 211(6): 1231-1242
  3. Angata, T. et al. (2006) Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. FASEB J. 20(12): 1964-1973

Related products for
Siglec-5/Siglec-14 Antibody, anti-human, REAfinity™

3 products available