Clone:
REA1048
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
PRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2)

Specifications for Siglec-10 Antibody, anti-human, REAfinity™

Overview

Clone REA1048 recognizes the human siglec-10 antigen, also known as sialic acid-binding Ig-like lectin 10, which is a member of the CD33-related group of siglecs. The cytoplasmic tail of siglec-10 contains four tyrosines, two of which are embedded in ITIM-signaling motifs and are likely to be involved in intracellular signaling. Amongst peripheral blood leucocytes, siglec-10 was found to be expressed on eosinophils, monocytes, and B cells. Higher levels of siglec-10 were found on a minor subset of NK-like cells that express the CD16 low-affinity Fc receptor but lack the CD56 antigen. The molecular properties and expression pattern suggest that siglec-10 may have evolved to function as an inhibitory receptor of the innate immune system.
Additional information: Clone REA1048 displays negligible binding to Fc receptors.

Alternative names

PRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2)

Detailed product information

Technical specifications

CloneREA1048
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenSiglec-10
Alternative names of antigenPRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2)
Molecular mass of antigen [kDa]75
Distribution of antigenB cells, monocytes, eosinophils
Entrez Gene ID89790
RRIDAB_2733712, AB_2733713, AB_2733299, AB_2733300, AB_2732929, AB_2732930

Resources for Siglec-10 Antibody, anti-human, REAfinity™

References for Siglec-10 Antibody, anti-human, REAfinity™

Publications

  1. Munday, J. et al. (2001) Identification, characterization, and leucocyte expression of siglec-10, a novel human sialic acid-binding receptor. Biochem. J. 355: 489-497
  2. Kitzig, F. et al. (2002) Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. Biochem. Biophys. Res. Commun. 296(2): 355-362
  3. Bandala-Sanchez, E. et al. (2013) T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10. Nat. Immunol. 14(7): 741-748

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