The SARS-CoV-2 Spike (S) glycoprotein mediates the entry of the virus into target cells via its interaction with the angiotensin-converting enzyme 2 (ACE2) receptor, thereby initiating the infection. It forms a homotrimeric structure on the surface of the SARS-CoV-2 virus and represents the major target for diagnostic and therapeutic agents. The ectodomain of the S glycoprotein comprises the N-terminal S1 subunit, including the receptor binding domain, and, the C-terminal S2 subunit.
SARS-CoV-2 Spike-Trimer (HEK) protein covers the ectodomain of the viral surface protein including amino acids V16 to K1211 and contains the stabilizing