Clone:
6A8.6F10.1A6
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
mouse IgG1, mouse IgG1κ
Applications:
FA, FC
Alternative names:
H2-T23

Specifications for QA-1B Antibody, anti-mouse

Overview

Clone 6A8.6F10.1A6 recognizes murine QA-1B, a 48 kDa non-classical MHC class Ib molecule encoded by the H2-T23 gene on chromosome 17. QA-1 associates with β2-microglobulin and its surface expression is found on activated hematopoietic cells, T cells, dendritic cells (DCs), macrophages, and neurons. Murine QA-1 presents a nine amino acid peptide called QA-1 determinant modifier (Qdm), peptides from proteins associated with infectious or inflammatory response, and a heat shock protein 60 (HSP60)–derived peptide (in the absence of Qdm) to immunoregulatory CD8
+
T cells. QA-1B also serves as a ligand for C-type lectin CD94/NKG2 receptors and depending on the NKG2 family member involved, this interaction can result in an inhibitory or an activating signal.

Alternative names

H2-T23

Detailed product information

Technical specifications

Clone6A8.6F10.1A6
Clonalitymonoclonal
Isotypemouse IgG1κ, mouse IgG1
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenQA-1B
Alternative names of antigenH2-T23
Molecular mass of antigen [kDa]39
Distribution of antigenT cells, dendritic cells, macrophages, neurons, stem cells, hematopoietic stem and progenitor cells
Entrez Gene ID15040
RRIDAB_2653304, AB_2653305, AB_2653299

Resources for QA-1B Antibody, anti-mouse

References for QA-1B Antibody, anti-mouse

Publications

  1. Lu, L. et al. (2007)
    Regulation of activated CD4
    +
    T cells by NK cells via the Qa-1-NKG2A inhibitory pathway.
    Immunity 26(5): 593-604
  2. Vance, R. E. et al. (1999) Recognition of the class Ib molecule Qa-1b by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. J. Exp. Med. 190: 1801-1812
  3. Lu, L. et al. (2006) The immunoregulatory effects of Qa-1. Immunol. Rev. 212: 51-59

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QA-1B Antibody, anti-mouse

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