TLR7/8/9 antagonists consist of short single-stranded oligodeoxynucleotides. They can inhibit CpG ODN-mediated activation of TLR9 and/or activation of TLR7/8.
ODN 2088 Control (ODN 20959) is a TLR7/8 antagonist but also acts as a TLR9 antagonist control. The sequence can form G-Tetrad structures.

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