Clone:
REA576
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Oligodendrocyte marker O4

Specifications for O4 Antibody, anti-human/mouse/rat, REAfinity™

Overview

Clone REA576 recognizes the human, mouse, and rat O4 antigen, a marker for oligodendrocytes, which are a type of glial cells. Their function is to provide a supporting role for neurons. During oligodendrocyte development, late A2B5
+
oligodendrocyte progenitors start to express O4. As the cells differentiate, A2B5 expression ceases, whereas O4 expression persists. More mature cells start to synthesize galactocerebroside, MBP, PLP, MOG, and O1. O4 expression is found on Schwann cells in the peripheral nervous system.
Additional information: Clone REA576 displays negligible binding to Fc receptors.

Alternative names

Oligodendrocyte marker O4

Detailed product information

Technical specifications

CloneREA576
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat
AntigenO4
Alternative names of antigenOligodendrocyte marker O4
Distribution of antigenSchwann cells
RRIDAB_2733889, AB_2751960, AB_2751913, AB_2752000, AB_2751969, AB_2733888

Resources for O4 Antibody, anti-human/mouse/rat, REAfinity™

References for O4 Antibody, anti-human/mouse/rat, REAfinity™

Publications

  1. Sommer, I. and Schachner, M. (1981) Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: an immunocytological study in the central nervous system. Dev. Biol. 83: 311-327
  2. Bansal, R. et al. (1989) Multiple and novel specificities of monoclonal antibodies O1, O4, and R-mAb used in the analysis of oligodendrocyte development. J. Neurosci. Res. 24(4): 548-557
  3. Zhang, S.C. (2001) Defining glial cells during CNS development. Nat. Rev. Neurosci. 2: 840-843

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