Clone:
REA704
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
NR4A1, TR3, NGFI-B, NAK1, N10, TISI

Specifications for Nur77 Antibody, anti-mouse, REAfinity™

Overview

Clone REA704 recognizes the mouse Nur77 antigen, a member of the steroid/ thyroid hormone receptor superfamily of intracellular transcription factors. Nur77 is an inducible orphan nuclear receptor also known as NR4A1 or nerve growth factor IB (NGFI-B) and plays a role in cell cycle mediation, inflammation, and apoptosis and is involved in mediation of inflammatory responses in macrophages. Nur77 expression is found on thymocytes and T cell lines and is mainly expressed in testis but also in brain and muscle tissue.
Additional information: Clone REA704 displays negligible binding to Fc receptors.

Alternative names

NR4A1, TR3, NGFI-B, NAK1, N10, TISI

Detailed product information

Technical specifications

CloneREA704
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse, human
Cross-reactivityhuman
AntigenNur77
Alternative names of antigenNR4A1, TR3, NGFI-B, NAK1, N10, TISI
Molecular mass of antigen [kDa]65
Distribution of antigenT cells, thymocytes, brain, muscle, testicle
Entrez Gene ID15370
RRIDAB_2653069, AB_2653070, AB_2653071, AB_2653068

Resources for Nur77 Antibody, anti-mouse, REAfinity™

References for Nur77 Antibody, anti-mouse, REAfinity™

Publications

  1. Cunningham, N. R. et al. (2006)
    Immature CD4
    +
    CD8
    +
    thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation.
    J. Immunol. 177(10): 6660-6666
  2. Pei, L. et al. (2006) Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol Endocrinol. 20(4): 786-794
  3. Tao, R. et al. (2008)
    Resistance of Foxp3
    +
    regulatory T cells to Nur77-induced apoptosis promotes allograft survival.
    PLoS One 3(5): e2321

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