Notch1 Antibody, anti-mouse
Clone:
22E5
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC
Alternative names:
Mis6, N1, TAN-1, lin-12

Specifications for Notch1 Antibody, anti-mouse

Overview

Notch1 is a 300 kDa member of the Notch family of type I transmembrane glycoproteins. Following cleavage in the Golgi, Notch forms a heterodimer composed of a 180-200 kDa disulfide-linked extracellular domain, and a 120 kDa membrane-bound intracellular portion. Upon ligand binding the latter is cleaved to form the notch intracellular domain transcription factor. Notch signaling controls cell fate decisions and is involved in multiple cellular differentiation steps during embryonic development and in adult organisms. In the immune system, Notch1 plays a non-redundant role for thymic T cell development
1
. Notch1 is also expressed by peripheral T cells and upregulated upon T cell activation
2
. The 22E5 antibody reacts with the extracellular part of the murine Notch1 protein.

Alternative names

Mis6, N1, TAN-1, lin-12

Detailed product information

Technical specifications

Clone22E5
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenNotch1
Alternative names of antigenMis6, N1, TAN-1, lin-12
Molecular mass of antigen [kDa]269
Entrez Gene ID18128
RRIDAB_2653051, AB_2653052, AB_2653050

Resources for Notch1 Antibody, anti-mouse

Certificates

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References for Notch1 Antibody, anti-mouse

Publications

  1. Fiorini, E. et al. (2009) Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. J Immunol 183(11): 7212-7222
  2. Radtke, F. et al. (2010) Notch signaling in the immune system. Immunity 32(1): 14-27

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