MSCA-1 Antibody, anti-human, REAfinity™
Clone:
REA781
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP

Specifications for MSCA-1 Antibody, anti-human, REAfinity™

Overview

Clone REA781 recognizes the human mesenchymal stromal cell antigen-1 (MSCA-1) antigen, a GPI-anchored protein also known as tissue non-specific alkaline phosphatase (TNAP). MSCA-1 was shown to be restricted to mesenchymal stromal cells (MSCs) in the CD271
bright
population in bone marrow. These CD271
bright
CD45
dim
MSCs have a much higher clonogenic capacity compared to the CD271
+
CD45
+
fraction in bone marrow. Therefore, MSCA-1 is a suitable marker to identify MSCs with a high proliferative potential.
Additional information: Clone REA781 displays negligible binding to Fc receptors.

Alternative names

ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP

Detailed product information

Technical specifications

CloneREA781
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate, other
Cross-reactivitydog, pig, sheep, goat, monkey
AntigenMSCA-1
Alternative names of antigenALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP
Molecular mass of antigen [kDa]53
Distribution of antigenother, bone marrow
Entrez Gene ID249
RRIDAB_2652962, AB_2652963, AB_2652964, AB_2652965, AB_2652966, AB_2652967, AB_2652968, AB_2725824, AB_2725823, AB_2652961

Resources for MSCA-1 Antibody, anti-human, REAfinity™

Documents and Protocols

Scientific posters

Sorting of MSCs with CD271 and MSCA-1 antibodies in a closed-cartridge system using the MACSQuant® Tyto® Sorter

Scientific posters

Standardized quantification of human bone marrow mesenchymal stromal cells based on a flow cytometry assay

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for MSCA-1 Antibody, anti-human, REAfinity™

Publications

  1. Battula, V. L. et al. (2007) Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Differentiation 75: 279-291
  2. Bühring, H. J. et al. (2007) Novel markers for the prospective isolation of human MSC. Ann. N. Y. Acad. Sci. 1106: 262-271
  3. Rozemuller, H. et al. (2010) Prospective isolation of mesenchymal stem cells from multiple mammalian species using cross-reacting anti-human monoclonal antibodies. Stem Cells Dev. 19: 1911-1921
  4. Sobiesiak, M. et al. (2010) The mesenchymal stem cell antigen MSCA-1 is identical to tissue non-specific alkaline phosphatase. Stem Cells Dev. 19: 669-677

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