Clone:
REA1139
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
MT

Specifications for Metallothionein Antibody, anti-human, REAfinity™

Overview

Clone REA1139 recognizes the human Metallothionein, a cytoplasmatic protein, which has a high content of cysteine and no aromatic amino acids. Metallothionein is able to bind and sequestrate heavy metal ions and is transcriptionally regulated by heavy metals, glucocorticoids, interferon, lymphokines and stress. The isoforms of Metallothionein MT I and MT II have the ability to scavenge free radicals and play a role in carcinogenesis. Overexpression is found in cancers, e.g. different carcinomas and melanoma.
Additional information: Clone REA1139 displays negligible binding to Fc receptors.

Alternative names

MT

Detailed product information

Technical specifications

CloneREA1139
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenMetallothionein
Alternative names of antigenMT
Molecular mass of antigen [kDa]6,1(average of subunits)
Distribution of antigentumor cells, tumor, melanoma
Entrez Gene ID4502, 4489, 4490, 4493, 4494, 4495, 4496, 4500, 4499, 4501
RRIDAB_2857483, AB_2857484, AB_2857482

References for Metallothionein Antibody, anti-human, REAfinity™

Publications

  1. Kägi, J.H. et al. (1974) Equine hepatic and renal metallothioneins. Purification, molecular weight, amino acid composition, and metal content. J. Biol. Chem. 249(11): 3537-3542
  2. Kumari, M. V. et al. (1998) Free radical scavenging actions of metallothionein isoforms I and II. Free Radic. Res. 29(2): 93-101
  3. Tuccari, G. et al. (2000) Immunohistochemical detection of metallothionein in carcinomatous and normal human gastric mucosa. Histol. Histopathol. 15(4): 1035-1041