Background information
Epstein-Barr virus (EBV) is a human γ-herpesvirus with B cell growth–transforming ability and carcinogenic potential. More than 90% of human adults are infected with EBV. In healthy individuals, EBV typically establishes a persistent latent infection, in which the virus can be detected in resting, non-proliferating peripheral B lymphocytes.
MACS GMP PepTivator EBV Select is a peptide pool that consists of 43 lyophilized MHC class I and class II restricted peptides derived from 15 different proteins from Epstein-Barr virus (EBV): LMP2a; BRLF1; BMLF1 (EB2); BNLF1 (LMP1); BERF3 (EBNA6); BERF1 (EBNA3); BERF2 (EBNA4); BALF2 (DNBI); BMRF1; BZLF1; BNRF1 (MTP); EBNA1; BLLF1 (gp350); BXLF2; EBNA2. The peptides are restricted for the following HLA-molecules: HLA-A*02, -A*03, -A*ll, -A*24, -A*26, -B*07, -B*08, -B*15, -B*18, -B*27, -B*35, -B*40, -B*4402, -DR.
Quality statement
MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
