CD83 antibodies, human

CD83 antibodies, human

Clone: REA714 | Dilution: 1:50
Clone REA714 recognizes the human CD83 antigen, a 45 kDa glycoprotein member of the immunoglobulin superfamily of receptors. In humans, CD83 is expressed on the surface of activated dendritic cells (DCs) and can therefore be used as a marker for the phenotypical characterization of DC maturation. CD83 plays a role in antigen presentation and lymphocyte activation.
Additional information: Clone REA714 displays negligible binding to Fc receptors.

Alternative names

B-cell activation protein

Technical specifications

  • Antigen: CD83
  • Clone: REA714
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: B-cell activation protein
  • Entrez Gene ID: 9308
  • Molecular mass of antigen [kDa]: 21
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    , baboon, horse
  • Distribution of antigen: lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770
  • Selected references

    1. Zhou, L.-J. et al. (1992) A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of J. Immunol. 149: 735-742
    2. Sallusto, F. and Lanzavecchia, A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179: 1109-1118
    3. Zhou, L.-J. and Tedder, T. F. (1995) Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol. 154: 3821-3835
    4. Lechmann, M. et al. (2002) CD83 on dendritic cells: more than just a marker for maturation. Trends Immunol. 23: 273-275
    5. Cao, W. et al. (2005) CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells. Biochem. J. 385: 85-93
Product options: 10
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00
130-110-561

CD83-PE, human

for 30
tests
(1)
EUR  125,00
130-110-503

CD83-PE, human

for 100
tests
(1)
EUR  310,00
130-110-562

CD83-APC, human

for 30
tests
(1)
EUR  125,00
130-110-504

CD83-APC, human

for 100
tests
(1)
EUR  310,00
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00

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