CD83 antibodies, human

CD83 antibodies, human

Clone: HB15 | Dilution: 1:11
The CD83 antibody reacts with a 45 kDa glycoprotein member of the immunoglobulin superfamily of receptors, also known as HB15. In humans, CD83 is expressed on the surface of activated dendritic cells (DCs) and can therefore be used as a marker for the phenotypical characterization of DC maturation. CD83 plays a role in antigen presentation and lymphocyte activation.

Alternative names

BL11, HB15

Technical specifications

  • Antigen: CD83
  • Clone: HB15
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: BL11, HB15
  • Entrez Gene ID: 9308
  • Molecular mass of antigen [kDa]: 21
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    , baboon, horse
  • Distribution of antigen: B cells, brain, dendritic cells, Langerhans cells, spleen, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio770, Biotin, PE
  • Selected references

    1. Zhou, L.-J. et al. (1992) A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of J. Immunol. 149: 735-742
    2. Zhou, L.-J. and Tedder, T. F. (1995) Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol. 154: 3821-3835
    3. Cao, W. et al. (2005) CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells. Biochem. J. 385: 85-93
    4. Lechmann, M. et al. (2002) CD83 on dendritic cells: more than just a marker for maturation. Trends Immunol. 23: 273-275
    5. Sallusto, F. and Lanzavecchia, A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179: 1109-1118
Product options: 6
130-094-181

CD83-PE, human

for 100
tests
(1)
EUR  310,00
130-098-889

CD83-APC, human

for 30
tests
(1)
EUR  125,00
130-094-186

CD83-APC, human

for 100
tests
(1)
EUR  310,00
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00
for 100
tests
(1)
EUR  260,00

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