CD81 antibodies, human

CD81 antibodies, human

Clone: REA513 | Dilution: 1:11
Clone REA513 recognizes the human CD81 antigen, a multi-pass membrane protein also known as TAPA-1. It is a member of the tetraspanin family including, for example, CD9, CD37, CD53, CD63, CD82, and CD151. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth, and motility. The 26 kDa cell surface protein is involved in adhesion, activation, proliferation, and differentiation of B cells, T cells, and other cells. On B cells CD81 is part of a complex with CD21, CD19, and Leu13. Similarly on T cells CD81 associates with CD4 and CD8 and provides a costimulatory signal with CD3. CD81 is expressed by epithelial and endothelial cells, T and B cells, as well as natural killer (NK) cells.
Additional information: Clone REA513 displays negligible binding to Fc receptors.

Alternative names

CVID6, S5.7, TAPA1, TSPAN28

Technical specifications

  • Antigen: CD81
  • Clone: REA513
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CVID6, S5.7, TAPA1, TSPAN28
  • Entrez Gene ID: 975
  • Molecular mass of antigen [kDa]: 26
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
  • Distribution of antigen: epithelial cells, endothelial cells, T cells, B cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE-Vio770, APC-Vio770, PerCP-Vio700
  • Selected references

    1. Oren, R. (1990) TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. Mol. Cell. Biol. 10(8): 4007-4015
    2. Levy, S. (1991) Structure and membrane topology of TAPA-1. J. Biol. Chem. 266(22): 14597-14602
    3. Wright, M. D. et al. (1994) The ins and outs of the transmembrane 4 superfamily. Immunol. Today 15(12): 588-594
    4. Levy, S. (1998) CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu. Rev. Immunol. 16: 89-109
Product options: 8
130-107-981

CD81-FITC, human

for 30
tests
(1)
EUR  105,00
130-107-919

CD81-FITC, human

for 100
tests
(1)
EUR  260,00
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00

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