CD62E antibodies, human

CD62E antibodies, human

Clone: REA280 | Dilution: 1:11
Clone REA280 recognizes the CD62 antigen-like family member E (CD62E) antigen, a 115 kDa single-pass type I membrane protein which is also known as E-selectin, endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2). CD62E is a cell adhesion molecule highly expressed only on endothelial cells activated by cytokines. It is not stored in the cell and has to be transcribed, translated, and transported to the cell surface. The production of CD62E is stimulated by the expression of CD62P which is stimulated by tumor necrosis factor α, and it can also be stimulated by interleukin-1 and lipopolysaccharide. CD62E recognizes and binds to sialylated carbohydrates present on the surface proteins of certain leukocytes. CD62E ligands are expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, and natural killer cells. Each of these cell types is found in acute and chronic inflammatory sites in association with expression of CD62E, thus implicating CD62E in the recruitment of these cells to such inflammatory sites.
Additional information: Clone REA280 displays negligible binding to Fc receptors.

Alternative names

SELE, Elam, ESEL, LECAM2, ELAM-1, E-selectin

Technical specifications

  • Antigen: CD62E
  • Clone: REA280
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SELE, Elam, ESEL, LECAM2, ELAM-1, E-selectin
  • Entrez Gene ID: 6401
  • Molecular mass of antigen [kDa]: 65
  • Distribution of antigen: neutrophils, monocytes, eosinophils, lymphocytes, NK cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Hession, C. et al. (1990) Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions. Proc. Natl. Acad. Sci. U.S.A. 87(5): 1673-1677
    2. Walzog, B. et al. (2000) Adhesion molecules: the path to a new understanding of acute inflammation. News Physiol. Sci. 15: 107-113
    3. Somers, W. S. et al. (2000) Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell 103(3): 467-479
Product options: 8
130-104-684

CD62E-PE, human

for 30
tests
(1)
EUR  125,00
130-104-643

CD62E-PE, human

for 100
tests
(1)
EUR  310,00
130-104-685

CD62E-APC, human

for 30
tests
(1)
EUR  125,00
130-104-644

CD62E-APC, human

for 100
tests
(1)
EUR  310,00
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00
for 30
tests
(1)
EUR  105,00
for 100
tests
(1)
EUR  260,00

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