CD59a antibodies, mouse

CD59a antibodies, mouse

Clone: REA287 | Dilution: 1:10
Clone REA287 recognizes the CD59a antigen, the murine analog of human CD59 which is also known as MAC-inhibitory protein (MAC-IP) or membrane attack complex inhibition factor (MACIF). CD59a is widely distributed, being present on all circulating cells, epithelia, and endothelia and in most tissues examined. CD59a blocks the formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex, hereby protecting the cells from complement-mediated lysis. Further, CD59a down-modulates CD4
+
T cell activity
in vitro
and
in vivo
, thereby revealing another link between complement regulators and T cell activation.
Additional information: Clone REA287 displays negligible binding to Fc receptors.

Alternative names

MAC-inhibitory protein (MAC-IP), Membrane attack complex inhibition factor (MACIF), Protectin, CD59

Technical specifications

  • Antigen: CD59a
  • Clone: REA287
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: MAC-inhibitory protein (MAC-IP), Membrane attack complex inhibition factor (MACIF), Protectin, CD59
  • Entrez Gene ID: 12509
  • Molecular mass of antigen [kDa]: 8
  • Distribution of antigen: leukocytes, epithelial cells, endothelial cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Longhi, M. P. et al. (2005) Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner. J. Immunol. 175(11): 7098-7102
    2. Powell, M. B. et al. (1997) Molecular cloning, chromosomal localization, expression, and functional characterization of the mouse analogue of human CD59. J. Immunol. 158(4): 1692-1702
    3. Harhausen, D. et al. (2010) Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice. J. Neuroinflammation 4(7): 15
Product options: 8
130-104-143

CD59a-PE, mouse

9 µg in 300 µL (1)
EUR  28,00
130-104-105

CD59a-PE, mouse

30 µg in 1 mL (1)
EUR  90,00
130-104-142

CD59a-APC, mouse

9 µg in 300 µL (1)
EUR  42,00
130-104-104

CD59a-APC, mouse

30 µg in 1 mL (1)
EUR  90,00
9 µg in 300 µL (1)
EUR  53,00
30 µg in 1 mL (1)
EUR  120,00
9 µg in 300 µL (1)
EUR  18,00
30 µg in 1 mL (1)
EUR  50,00

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