CD324 (E-Cadherin) antibodies, human

CD324 (E-Cadherin) antibodies, human

Clone: REA811 | Dilution: 1:50
Clone REA811 recognizes CD324, also known as E-cadherin or cadherin-1, which is a calcium-dependent cell adhesion protein found in adherence junctions of epithelial cells, e.g., in colon, uterus, liver, keratinocytes, etc. E-cadherin also serves as a ligand for integrin α-E/β-7. The epitope is expressed by a variety of carcinoma-derived cell lines such as MCF-7, HT-29, T-47D, NTERA-2, and 2102Ep. Loss of E-cadherin is thought to enable metastasis by disrupting intercellular contacts – an early step in metastatic dissemination. Furthermore, E-cadherin is a marker of undifferentiated embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. For these cells, E-cadherin plays a major role in conveying cell survival signals.
Additional information: Clone REA811 displays negligible binding to Fc receptors

Alternative names

CDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin, Cadherin-1

Technical specifications

  • Antigen: CD324 (E-Cadherin)
  • Clone: REA811
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin, Cadherin-1
  • Entrez Gene ID: 999
  • Molecular mass of antigen [kDa]: 80
  • Distribution of antigen: epithelial cells, platelets, ES and iPS cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Onder, T. T. et al. (2008) Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 68: 3645-3654
    2. Eastham, A. M. et al. (2007) Epithelial-mesenchymal transition events during human embryonic stem cell differentiation. Cancer Res. 67: 11254-11262
    3. Higgins, J. M. et al. (1998) Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin. J. Cell Biol. 140: 197-210
    4. Li, Z. et al. (2010) Spatially resolved quantification of E-cadherin on target hES cells. J. Phys. Chem. B 114: 2894-2900
Product options: 12
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EUR  140,00
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EUR  310,00
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tests
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EUR  125,00
for 100
tests
(1)
EUR  310,00
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00
for 30
tests
(1)
EUR  105,00
for 100
tests
(1)
EUR  260,00

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