CD279 (PD1) antibodies – functional grade, human

CD279 (PD1) antibodies – functional grade, human

Clone: PD1.3.1.3
PD1.3.1.3 recognizes human CD279, also known as programmed death-1 (PD-1). It is a 55 kDa transmembran protein belonging to the CD28/CTLA-4 family. It is expressed on T cells, B cells, NK cells, and activated myeloid cells. CD279 is not expressed on naive T cells but induced after activation and expressed on late, differentiated T cells. The ligands PD-L1 (B7-H1; CD274) and PD-L2 (B7-DC; CD273) belong to the B7 immunglobulin superfamily. PD1 and its ligands mediate inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology. Clone PD.1.3.1.3 has been used to block the binding of both ligands.

Applications

This pure – functional grade antibody is suited for cell culture functional assays, for example, blocking of receptor-ligand binding.

Alternative names

PDCD1, PD1, SLEB2, hPD-1, hPD-l, hSLE1

Technical specifications

  • Antigen: CD279 (PD1)
  • Clone: PD1.3.1.3
  • Isotype: mouse IgG2b
  • Alternative names of antigen: PDCD1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
  • Entrez Gene ID: 5133
  • Molecular mass of antigen [kDa]: 29
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: B cells, monocytes, spleen, T cells, thymocytes
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Keir, M. E. et al. (2008) PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26: 677-704
    2. Okazaki, T. and Honjo, T. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int. Immunol. 19: 813-824
    3. Serriari, N.-E. et al. (2010) B and T lymphocyte attenuator is highly expressed on CMV-specific T cells during infection and regulates their function. J. Immunol. 185: 3140-3148
Product options: 1
500 µg in 0.5 mL
EUR  350,00

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