CD26 antibodies, mouse

CD26 antibodies, mouse

Clone: H194-112 | Dilution: 1:50
Clone H194-112 recognizes the mouse CD26 antigen, a 220 kDa single-pass type II membrane protein also known as dipeptidyl peptidase 4 (Dpp4) or thymocyte-activating molecule (THAM). CD26 is a multifunctional glycoprotein expressed both as a soluble form in plasma and on the surface of several cell types, including epithelial and endothelial cells. In the immune system CD26 is expressed on thymocytes, activated T cells, B cells, NK cells, and macrophages. It has been involved in T cell costimulation, tumor suppression, and adenosine deaminase binding. In addition, CD26 is a serine protease belonging to a subgroup of prolyl oligopeptidases, whose members specifically cleave off N-terminal dipeptides from proteins having proline or alanine in amino acid position 2. The biological activity of several hormones and chemokines can be abolished by CD26
in vitro
. Thus, CD26 has been implicated in the regulation of immune, inflammatory, nervous, and endocrine functions.

Alternative names

Dpp4, THAM, DPP IV

Technical specifications

  • Antigen: CD26
  • Clone: H194-112
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: Dpp4, THAM, DPP IV
  • Entrez Gene ID: 13482
  • Molecular mass of antigen [kDa]: 87
  • Distribution of antigen: endothelial cells, epithelial cells, thymocytes, B cells, T cells, macrophages, NK cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Marguet, D. et al. (2000) Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc. Natl. Acad. Sci. U.S.A. 97(12): 6874-6879
    2. Marguet, D. et al. (1992) cDNA cloning for mouse thymocyte-activating molecule. A multifunctional ecto-dipeptidyl peptidase IV (CD26) included in a subgroup of serine proteases. J. Biol. Chem. 267(4): 2200-2208
    3. Matteucci, E. et al. (2009) Dipeptidyl peptidase-4 (CD26): knowing the function before inhibiting the enzyme. Curr. Med. Chem. 16(23): 2943-2951
Product options: 1
130-119-652

CD26-PE, mouse

30 µg in 200 µL (1)
EUR  90,00

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