CD254 (RANKL) antibodies, human

CD254 (RANKL) antibodies, human

Clone: DN254 | Dilution: 1:11
Clone DN254 recognizes the human CD254 antigen, also known as receptor activator of nuclear factor kappa-B ligand (RANKL) or TNF-related activation-induced cytokine (TRANCE). CD254 is an essential osteoclastic differentiation and activation factor which plays multiple roles in the immune system. It is reported, that RANK and CD254 (RANKL) may be important regulators of interactions between T cells and dendritic cells and is involved in the regulation of the T cell–dependent immune response. CD254 is expressed in the peripheral lymph nodes, in spleen, peripheral blood leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach, and thyroid.

Alternative names

TNFSF11, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf

Technical specifications

  • Antigen: CD254 (RANKL)
  • Clone: DN254
  • Isotype: human IgG2
  • Alternative names of antigen: TNFSF11, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
  • Entrez Gene ID: 8600
  • Molecular mass of antigen [kDa]: 36
  • Distribution of antigen: lymph node, spleen, leukocytes, bone marrow, heart, placenta, skeletal muscle
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Anderson, D. M. et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390(6656): 175-179
    2. Bekker, P. J. et al. (2004) A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J. Bone Miner. Res. 19(7): 1059-1066
    3. Luan, X. et al. (2012) Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin. J. Immunol. 189(1): 245-252
Product options: 6
for 30
tests
(1)
EUR  125,00
for 100
tests
(1)
EUR  310,00
for 30
tests
(1)
EUR  125,00
for 100
tests
(1)
EUR  310,00
for 30
tests
(1)
EUR  105,00
for 100
tests
(1)
EUR  260,00