CD240DCE antibodies, human

CD240DCE antibodies, human

Clone: REA327 | Dilution: 1:11
Clone REA327 recognizes the human CD240DCE antigens, multi-pass membrane proteins which are also known as blood group Rhesus (DCE) polypeptides. The Rhesus (Rh) blood group system is the most clinically significant blood group system after ABO. At present, the Rh blood group system consists of 50 defined blood-group antigens, among which the antigens D, C, and E are the most important. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic CD240D (RhD) protein on the surface of erythrocytes. Besides its role in blood transfusion, the Rh blood group system – specifically, the CD240D antigen – is used to determine the risk of hemolytic disease of the newborn as prevention is the best approach to the management of this condition.
Additional information: Clone REA327 displays negligible binding to Fc receptors.

Alternative names

RHCE, RHD, Rh polypeptide 2 (RhPII), Rhesus D antigen, Blood group Rh(CE) polypeptide (RHCE)

Technical specifications

  • Antigen: CD240DCE
  • Clone: REA327
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: RHCE, RHD, Rh polypeptide 2 (RhPII), Rhesus D antigen, Blood group Rh(CE) polypeptide (RHCE)
  • Entrez Gene ID: 6007, 6006
  • Molecular mass of antigen [kDa]: 45
  • Distribution of antigen: red blood cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Smythe, J. S. et al. (1996) Expression of RHD and RHCE gene products using retroviral transduction of K562 cells establishes the molecular basis of Rh blood group antigens. Blood 87(7): 2968-2973
    2. Wagner, F. F. et al. (2000) RHD gene deletion occurred in the Rhesus box. Blood 95(12): 3662-3668
    3. Wagner, F. F. et al. (2004) Review: the molecular basis of the Rh blood group phenotypes. Immunohematology 20(1): 23-36
Product options: 8
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EUR  315,00
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EUR  135,00
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EUR  315,00
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EUR  110,00
for 100
tests
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EUR  265,00

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