CD172g (SIRPγ) antibodies, human

CD172g (SIRPγ) antibodies, human

Clone: REA479 | Dilution: 1:11
Clone REA479 recognizes the human CD172g antigen, a single-pass type I membrane protein also known as signal-regulatory protein γ (SIRPγ) or signal-regulatory protein β 2 (SIRPβ2). Signal regulatory proteins (SIRPs) are a family of transmembrane receptor-like signaling proteins that are abundantly expressed in hematopoietic cells, including granulocytes, monocytes, dendritic cells, and lymphocytes. In addition, SIRPs are expressed in neuronal cells and certain types of cancer cells. CD172g is the only member of the SIRP family that is expressed on T cells, some B cells, CD56
bright
natural killer (NK) cells, and all activated NK cells. CD172g does bind CD47, albeit with less affinity than CD172a (SIRPα). This interaction mediates cell-cell adhesion, rather than inhibitory signals. The adhesion mediated by contact of CD172g on T cells with CD47 on antigen-presenting cells (APCs) promotes antigen-specific T cell proliferation and costimulates T cell activation.
Additional information: Clone REA479 displays negligible binding to Fc receptors.

Alternative names

SIRPG, SIRP-g, SIRPB2, SIRPgamma

Technical specifications

  • Antigen: CD172g (SIRPγ)
  • Clone: REA479
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SIRPG, SIRP-g, SIRPB2, SIRPgamma
  • Entrez Gene ID: 55423
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: B cells, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Ichigotani, Y. et al. (2000) Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family. J Hum Genet 45(6): 378-382
    2. Piccio, L. et al. (2005) Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. Blood 105(6): 2421-2427
    3. Stefanidakis, M. et al. (2008)
      Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions
      in vitro
      .
      Blood 112(4): 1280-1289
Product options: 8
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00
for 30
tests
(1)
EUR  125,00
for 100
tests
(1)
EUR  310,00
for 30
tests
(1)
EUR  125,00
for 100
tests
(1)
EUR  310,00
for 30
tests
(1)
EUR  105,00
for 100
tests
(1)
EUR  260,00

Related products

1 products available