CD146 (LSEC) antibodies, mouse

CD146 (LSEC) antibodies, mouse

Clone: ME-9F1 | Dilution: 1:10
The CD146 (LSEC) antibody (clone ME-9F1) binds to the CD146 antigen, which is expressed on mouse endothelial cells, including liver sinusoidal endothelial cells (LSECs), smooth muscle cells, and the basal membrane.
1
LSECs are microvascular endothelial cells lining the hepatic sinusoidal wall. Their strategic positioning favors a tight interaction with lymphocytes migrating through the liver. They possess a high capacity for antigen uptake and processing. However, in contrast to professional antigen-presenting cells (e.g. dendritic cells), they express only low levels of costimulatory molecules.
2

Alternative names

MCAM, 1-gicerin, CD149, MUC18, S-endo, s-gicerin, Endo-CAM, Mel-CAM

Technical specifications

  • Antigen: CD146 (LSEC)
  • Clone: ME-9F1
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: MCAM, 1-gicerin, CD149, MUC18, S-endo, s-gicerin, Endo-CAM, Mel-CAM
  • Entrez Gene ID: 84004
  • Molecular mass of antigen [kDa]: 69
  • Distribution of antigen: bone marrow, dendritic cells, endothelial cells, epithelial cells, fibroblasts, mesenchymal stem cells, ES and iPS cells, smooth muscle, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PerCP-Vio700, Biotin
  • Selected references

    1. Harder, R. et al. (1991) Dissection of murine lymphocyte-endothelial cell interaction mechanisms by SV-40-transformed mouse endothelial cell lines: novel mechanisms mediating basal binding, and alpha 4-integrin-dependent cytokine-induced adhesion. Exp. Cell Res. 197: 259-267
    2. Diehl, L. et al. (2008)
      Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8
      +
      T cell tolerance.
      Hepatology 47: 296-305
Product options: 12
9 µg in 300 µL (1)
EUR  25,00
30 µg in 1 mL (1)
EUR  50,00
9 µg in 300 µL (1)
EUR  32,00
30 µg in 1 mL (1)
EUR  90,00
9 µg in 300 µL (1)
EUR  46,00
30 µg in 1 mL (1)
EUR  90,00
9 µg in 300 µL (1)
EUR  67,00
30 µg in 1 mL (1)
EUR  110,00
9 µg in 300 µL (1)
EUR  53,00
30 µg in 1 mL (1)
EUR  120,00
9 µg in 300 µL (1)
EUR  18,00
30 µg in 1 mL (1)
EUR  50,00

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