Anti-VEGFR-1 (Flt-1) antibodies, human

Anti-VEGFR-1 (Flt-1) antibodies, human

Clone: REA569 | Dilution: 1:11
Clone REA569 recognizes the human VEGFR-1 antigen, also known as Flt-1, belonging to the class III subfamily of receptor tyrosine kinases. Vascular endothelial growth factors (VEGFs) stimulate cellular responses by binding to tyrosine kinase receptors on the cell surface, causing them to dimerize, and become activated through transphosphorylation. VEGFs are produced by endothelial, hematopoietic, and stromal cells in response to hypoxia and upon stimulation by growth factors such as transforming growth factor beta (TGF-β), interleukins, or platelet-derived growth factors (PDGFs).
Additional information: Clone REA569 displays negligible binding to Fc receptors

Alternative names

FLT1, FLT

Technical specifications

  • Antigen: VEGFR-1
  • Clone: REA569
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FLT1, FLT
  • Entrez Gene ID: 2321
  • Molecular mass of antigen [kDa]: 148
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: Biotin, PE
  • Selected references

    1. Shibuya, M. (2001) Structure and function of VEGF/VEGF-receptor system involved in angiogenesis. Cell Struct. Funct. 26(1): 25-35
    2. Riccioni, R. et al. (2007) Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. Stem Cells 25(8): 1862-1871
    3. Stuttfeld, E. et al. (2009) Structure and function of VEGF receptors. Int J Biochem Mol Biol 61(9): 915-922
    4. Grunewald, F. S. et al. (2010) Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling. Biochim. Biophys. Acta 1804(3): 567-580
Product options: 2
for 30
tests
(1)
EUR  110,00
for 100
tests
(1)
EUR  265,00