Anti-TCR Vγ9 antibodies, human

Anti-TCR Vγ9 antibodies, human

Clone: REA470 | Dilution: 1:11
Clone REA470 recognizes the human variable gamma 9 subunit of the γ/δ T cell receptor (TCR Vγ9). The T cell receptor is a heterodimeric glycoprotein associated with the CD3 antigen. The γ and δ TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. γδ T cells represent unconventional lymphocytes that share characteristics of natural killer (NK) cells and T cells and often express regulatory NK receptors, thereby linking innate and adaptive immunity. Upon cross-linking CD94/NKG2A, antigenic activation of γδ T cells is down-modulated by inhibiting cell proliferation, cytokine production, and cytotoxicity. γδ T cells can detect target cells with patterns of MHC class I expression altered as a result of tumor transformation or viral infection, thus endowing them with a role in immunosurveillance originally attributed to NK cells only. Vγ9/Vδ2 T cells comprise the majority of peripheral human γδ T cells and are capable of responding to the microbial metabolite HMB-PP.
Additional information: Clone REA470 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: TCR Vγ9
  • Clone: REA470
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Entrez Gene ID: 6983
  • Molecular mass of antigen [kDa]: 13
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, VioBlue, APC-Vio770, Biotin, FITC
  • Selected references

    1. Pár, G. et al. (2002)
      Decrease in CD3-negative-CD8
      dim+
      and Vdelta2/Vgamma9 TcR
      +
      peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection.
      J. Hepatol. 37(4): 514-522
    2. Eberl, M. et al. (2005) Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1). J. Leukoc. Biol. 77(1): 67-70
    3. Karunakaran, M. M. et al. (2014)
      Vγ9 and Vδ2 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (
      Vicugna pacos
      ).
      Immunogenetics 66(4): 243-254
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