Anti-Nur77 antibodies, mouse

Anti-Nur77 antibodies, mouse

Clone: REA704 | Dilution: 1:50
Clone REA704 recognizes the mouse Nur77 antigen, a member of the steroid/ thyroid hormone receptor superfamily of intracellular transcription factors. Nur77 is an inducible orphan nuclear receptor also known as NR4A1 or nerve growth factor IB (NGFI-B) and plays a role in cell cycle mediation, inflammation, and apoptosis and is involved in mediation of inflammatory responses in macrophages. Nur77 expression is found on thymocytes and T cell lines and is mainly expressed in testis but also in brain and muscle tissue.
Additional information: Clone REA704 displays negligible binding to Fc receptors.

Alternative names

NR4A1, TR3, NGFI-B, NAK1, N10, TISI

Technical specifications

  • Antigen: Nur77
  • Clone: REA704
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: NR4A1, TR3, NGFI-B, NAK1, N10, TISI
  • Entrez Gene ID: 15370
  • Molecular mass of antigen [kDa]: 65
  • Cross-reactivity: human
  • Distribution of antigen: thymocytes, T cells, brain, muscle, testicle
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Cunningham, N. R. et al. (2006)
      Immature CD4
      +
      CD8
      +
      thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation.
      J. Immunol. 177(10): 6660-6666
    2. Pei, L. et al. (2006) Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol Endocrinol. 20(4): 786-794
    3. Tao, R. et al. (2008)
      Resistance of Foxp3
      +
      regulatory T cells to Nur77-induced apoptosis promotes allograft survival.
      PLoS One 3(5): e2321
Product options: 4
30 µg in 200 µL (1)
EUR  90,00
150 µg in 1 mL (1)
EUR  315,00
30 µg in 200 µL (1)
EUR  90,00
150 µg in 1 mL (1)
EUR  315,00

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