Anti-MICA/MICB antibodies, human

Anti-MICA/MICB antibodies, human

Clone: 6D4 | Dilution: 1:11
The monoclonal antibody 6D4 recognizes MICA and MICB, which are transmembrane glycoproteins related to major histocompatibility complex (MHC) class I molecules. In contrast to other MHC class I proteins, MICA/B have no association with β2-microglobulin and do not bind peptides. They are ligands for NKG2D, which is expressed on NK cells and many T cells. MICA/B are expressed on endothelial cells and fibroblasts and are stress-induced in epithelial cells.

Alternative names

MICB, PERB11.2, MICA, PERB11.1

Technical specifications

  • Antigen: MICA/MICB
  • Clone: 6D4
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: MICB, PERB11.2, MICA, PERB11.1
  • Distribution of antigen: endothelial cells, fibroblasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Li, P. et al. (1999) Crystal structure of the MHC class I homolog MIC-A, a γδ T cell ligand. Immunity 10: 577-584
    2. Houchins, J. P. et al. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 173(4): 1017-1020
    3. Bauer, S. et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285: 727-729
Product options: 12
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EUR  310,00
for 30
tests
(1)
EUR  125,00
for 100
tests
(1)
EUR  310,00
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00
for 30
tests
(1)
EUR  140,00
for 100
tests
(1)
EUR  335,00
for 30
tests
(1)
EUR  105,00
for 100
tests
(1)
EUR  260,00

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