Anti-MEK1 antibodies, human and mouse

Anti-MEK1 antibodies, human and mouse

Clone: REA155 | Dilution: 1:11
Clone REA155 recognizes MEK1, a 45 KDa serine/threonine kinase and a component of the MAPK signal transduction cascade. In response to ligands such as growth factors, cytokines, and hormones, respective cell surface receptors are engaged and activate GTP-bound Ras, which transmits the signal by activating the protein kinases Raf-1, B-Raf, and A-Raf (Rafs), the MAP3K components of the cascade. MEK1 and the related kinase MEK2 are then the targets of MAP3K and transmit the signal further by phosphorylating the MAP kinases ERK1/ERK2. MAPK signal transduction pathway is involved in large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription.
Additional information: Clone REA155 displays negligible binding to Fc receptors.

Alternative names

MAP2K1, CFC3, MAPKK 1, MKK1, PRKMK1

Technical specifications

  • Antigen: MEK1
  • Clone: REA155
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: MAP2K1, CFC3, MAPKK 1, MKK1, PRKMK1
  • Entrez Gene ID: 5604
  • Molecular mass of antigen [kDa]: 43
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Davis, R. J. et al. (1995) Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42(4): 459-467
    2. Roskoski, R. et al. (2012) MEK1/2 dual-specificity protein kinases: structure and regulation. Biochem. Biophys. Res. Commun. 417(1): 5-10
Product options: 4
for 30
tests
(1)
EUR  125,00
for 100
tests
(1)
EUR  310,00
for 30
tests
(1)
EUR  125,00
for 100
tests
(1)
EUR  310,00

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