Clone:
YLI-90
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
mouse IgG1κ
Applications:
FA, FC
Alternative names:
Klra9, LY49I1

Specifications for Ly-49I Antibody, anti-mouse

Overview

Clone YLI-90 recognizes the mouse Ly-49I antigen, a single-pass type II C-type lectin-like membrane glycoprotein also known as Ly-49 inhibitory receptor I. The Ly-49 receptors are encoded by a family of highly polymorphic and polygenic genes within the mouse NK gene complex which includes genes that encode both inhibitory and activating Ly-49 receptors. Ly-49 receptors recognize MHC-I and MHC-I-like proteins on normal as well as altered cells. They are described as being expressed on both the developing and mature NK cells. The inhibitory Ly-49 receptors are involved in NK cell education, a process in which NK cells acquire function and tolerance toward cells that express “self-MHC-I.” On the other hand, the activating Ly-49 receptors recognize altered cells expressing activating ligands. Ly-49 receptors have been described on multiple NK cell subsets, such as uterine NK and memory NK cells, as well as NKT cells, dendritic cells, plasmacytoid dendritic cells, macrophages, neutrophils, and cells of the adaptive immune system, such as activated T cells and regulatory CD8
+
T cells. Ly-49I is an inhibitory receptor capable of down-modulating proliferation, IFN-γ response, and cytotoxic activity in cells that express it.

Alternative names

Klra9, LY49I1

Detailed product information

Technical specifications

CloneYLI-90
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenLy-49I
Alternative names of antigenKlra9, LY49I1
Molecular mass of antigen [kDa]31
Distribution of antigenNK cells, dendritic cells, macrophages, NKT cells, neutrophils
Entrez Gene ID16640
RRIDAB_2652778, AB_2652779, AB_2652780, AB_2652781, AB_2652782, AB_2652783, AB_2652784, AB_2652785, AB_2652786, AB_2652787, AB_2652777

Resources for Ly-49I Antibody, anti-mouse

References for Ly-49I Antibody, anti-mouse

Publications

  1. Wong, S. et al. (1991) Ly-49 multigene family. New members of a superfamily of type II membrane proteins with lectin-like domains. J. Immunol. 147(4): 1417-1423
  2. Regunathan, J. et al. (2005) NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors. Blood 105: 233-240
  3. Tu, M. M. et al. (2014) Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells. Cancer Res. 74(14): 3684-3694
  4. Dimasi, N. et al. (2002) Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family. J. Mol. Biol. 320(3): 573-585

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Ly-49I Antibody, anti-mouse

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