Clone:
A1
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2aκ
Applications:
FC
Alternative names:
Klra1, A1, CH29-493D4.3, Klra22, Ly49v

Specifications for Ly-49A Antibody, anti-mouse

Overview

Clone A1 recognizes Ly-49A, an inhibitory cell surface receptor belonging to the Ly-49 receptor family. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK-T cells. Ly-49 family members are both activating and inhibitory receptors and are mainly receptors for MHC class I molecules. Ly-49A interacts strongly with MHC class Ia molecules such as H-2D
d
, H-2D
k
and weakly with H-2D
b
. An inhibitory signal is delivered by Ly-49A engagement via the phosphorylation of immunoreceptor tyrosine based inhibition motif (ITIM) and recruitment of phosphatases SHP-1 and SHP-2. Recognition of cognate ligand bearing cells leads to inhibition of cytotoxic killing of cells by NK cells.

Alternative names

Klra1, A1, CH29-493D4.3, Klra22, Ly49v

Detailed product information

Technical specifications

CloneA1
Clonalitymonoclonal
Isotypemouse IgG2aκ
Isotype controlIsotype Control Antibody, mouse IgG2a
Hostmouse
Type of antibodyPrimary antibodies
Speciesmouse
AntigenLy-49A
Alternative names of antigenKlra1, A1, CH29-493D4.3, Klra22, Ly49v
Molecular mass of antigen [kDa]30
Entrez Gene ID16627
RRIDAB_2652674, AB_2652675, AB_2652676, AB_2652677, AB_2652678, AB_2652679, AB_2652680, AB_2652681, AB_2652682, AB_2652683, AB_2652684, AB_2652673

Resources for Ly-49A Antibody, anti-mouse

References for Ly-49A Antibody, anti-mouse

Publications

  1. Chung, D. H. et al. (2000) Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. J. Immunol. 165: 6922-6932
  2. Zimmer, J. et al. (2001)
    H-2D ligand expression by Ly49A
    +
    natural killer (NK) cells precludes ligand uptake from environmental cells: Implications for NK cell function.
    J. Exp. Med. 194(10): 1531-1539
  3. Daws, M. R. et al. (1999) H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1. Immunology 97(4): 656-664

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Ly-49A Antibody, anti-mouse

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