Type of antibody:
Primary antibodies
rat IgG2b
Alternative names:
Fex, GPR49

Specifications for LGR5 Antibody, anti-mouse


Clone DA04-10E8.9 recognizes the mouse LGR5 antigen, also known as leucine-rich-repeat-containing G-protein–coupled receptor 5 or Gpr49 but not with its close homologues LGR4 or LGR6. LGR5 associates with Wnt-receptors and act as R-spondin receptor thereby playing a central role in the modulation of Wnt/β-catenin signaling in normal and neoplastic stem cells. Initially described as a highly specific marker for stem cells in the small intestine, colon, hair follicle, stomach, and during kidney development, LGR5 positive cells were also shown to be crucial during the development and progression of cancer. It was shown that LGR5 positive crypt stem cells are the cells-of-origin in intestinal cancer and that CSCs in human colorectal cancer can be identified and isolated based on LGR5 expression.

Alternative names

Fex, GPR49

Detailed product information

Technical specifications

Isotyperat IgG2b
Isotype controlIsotype Control Antibody, rat IgG2b
Type of antibodyPrimary antibodies
Alternative names of antigenFex, GPR49
Molecular mass of antigen [kDa]97
Distribution of antigenstem cells, cancer stem cells
Entrez Gene ID14160
RRIDAB_2652634, AB_2652635, AB_2652636, AB_2652637, AB_2652638, AB_2652639, AB_2652640, AB_2819364, AB_2734116, AB_2652633

Resources for LGR5 Antibody, anti-mouse


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References for LGR5 Antibody, anti-mouse


  1. Barker, N. et al. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449(7165): 1003-1007
  2. Hermey, G. et al. (1999) Identification of a novel seven-transmembrane receptor with homology to glycoprotein receptors and its expression in the adult and developing mouse. Biochem. Biophys. Res. Commun. 254(1): 273-279
  3. Morita, H. et al. (2004) Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension. Mol. Cell. Biol. 24(22): 9736-9743
  4. Jaks, V. et al. (2008) Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat. Genet. 40: 1291-1299

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